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Amit S Kalgutkar Selected Research

Thiouracil

7/2018Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor.
2/2016Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans.

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Amit S Kalgutkar Research Topics

Disease

7Type 2 Diabetes Mellitus (MODY)
07/2022 - 02/2011
7Drug-Related Side Effects and Adverse Reactions
01/2017 - 06/2005
5Non-alcoholic Fatty Liver Disease
07/2022 - 01/2016
3COVID-19
01/2022 - 12/2021
3Cardiovascular Diseases (Cardiovascular Disease)
07/2018 - 11/2015
3Fibrosis (Cirrhosis)
05/2018 - 01/2017
3Metabolic Diseases (Metabolic Disease)
05/2018 - 01/2016
3Breast Neoplasms (Breast Cancer)
05/2016 - 11/2007
2Obesity
07/2022 - 06/2007
2Alcoholic Fatty Liver
07/2022 - 05/2018
2Inflammation (Inflammations)
01/2019 - 01/2016
2Diabetic Nephropathies (Diabetic Nephropathy)
01/2017 - 01/2016
2Dyslipidemias (Dyslipidemia)
11/2013 - 10/2012
2Osteoporosis
06/2010 - 06/2009
1Fatty Liver
11/2020
1Insulin Resistance
11/2020
1Myocardial Infarction
01/2019
1Atherosclerosis
01/2019
1Liver Diseases (Liver Disease)
05/2018
1Hypertrophy
01/2017
1Proteinuria
01/2017
1Cholestasis
10/2016
1Hyperbilirubinemia
10/2016
1Rhabdomyolysis
05/2016
1Muscular Diseases (Myopathy)
05/2016
1Heart Failure
09/2014
1Coronary Disease (Coronary Heart Disease)
07/2014
1Carcinoma (Carcinomatosis)
07/2014
1Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2013

Drug/Important Bio-Agent (IBA)

9Pharmaceutical PreparationsIBA
01/2022 - 06/2005
6Proteins (Proteins, Gene)FDA Link
01/2019 - 11/2007
4EnzymesIBA
07/2022 - 06/2007
4Peroxidase (Myeloperoxidase)IBA
01/2019 - 11/2015
4Peptides (Polypeptides)IBA
05/2016 - 11/2007
32- (6- (5- chloro- 2- methoxyphenyl)- 4- oxo- 2- thioxo- 3,4- dihydropyrimidin- 1(2H)- yl)acetamideIBA
01/2019 - 11/2015
3AnionsIBA
05/2016 - 11/2007
3G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
01/2013 - 02/2011
2FructoseIBA
07/2022 - 11/2020
2nirmatrelvirIBA
01/2022 - 01/2022
2nirmatrelvir and ritonavir drug combinationIBA
01/2022 - 01/2022
2Ritonavir (Norvir)FDA Link
01/2022 - 01/2022
2Glucose (Dextrose)FDA LinkGeneric
01/2019 - 09/2011
2ThiouracilIBA
07/2018 - 02/2016
2acetamideIBA
07/2018 - 02/2016
2AMP-Activated Protein KinasesIBA
05/2018 - 05/2017
2Anti-Infective Agents (Microbicides)IBA
10/2016 - 05/2016
2Fusidic Acid (Fucithalmic)IBA
10/2016 - 05/2016
2Atorvastatin (Lipitor)FDA Link
05/2016 - 11/2013
2Cytochrome P-450 CYP3AIBA
05/2016 - 11/2013
1ketohexokinaseIBA
07/2022
1PeptidomimeticsIBA
01/2022
1Protease Inhibitors (Protease Inhibitor)IBA
01/2022
1Peptide Hydrolases (Proteases)FDA Link
01/2022
1Antiviral Agents (Antivirals)IBA
12/2021
1VaccinesIBA
12/2021
1Acetyl-CoA CarboxylaseIBA
10/2020
1Lipoproteins (Lipoprotein)IBA
01/2019
1Messenger RNA (mRNA)IBA
05/2018
1CholesterolIBA
05/2018
1PF-6409577IBA
05/2018
1LipidsIBA
05/2018
1Isoproterenol (Isoprenaline)FDA LinkGeneric
01/2018
1compound 18IBA
01/2018
1CXC ChemokinesIBA
01/2018
1CarbonIBA
01/2017
1AminesIBA
01/2017
1Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
01/2017
1Biomarkers (Surrogate Marker)IBA
01/2017
1Blood Glucose (Blood Sugar)IBA
01/2017
1Ramipril (Altace)FDA LinkGeneric
01/2017
1Protein Isoforms (Isoforms)IBA
01/2017
1GlucuronidesIBA
10/2016
1BilirubinIBA
10/2016
1Anti-Bacterial Agents (Antibiotics)IBA
10/2016
1Simvastatin (Zocor)FDA LinkGeneric
05/2016
1Digoxin (Digitek)FDA LinkGeneric
05/2016
1Rosuvastatin Calcium (Crestor)FDA Link
05/2016
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
05/2016
1indoleIBA
01/2016
1Adenosine Monophosphate (AMP)IBA
01/2016
1Prostaglandin E Receptors (Prostaglandin E Receptor)IBA
01/2016
1Carboxylic AcidsIBA
01/2016
1Protein Kinases (Protein Kinase)IBA
01/2016
1GlucokinaseIBA
02/2015
16- (3- cyclopentyl- 2- (4- (trifluoromethyl)- 1H- imidazol- 1- yl)propanamido)nicotinic acidIBA
02/2015
1Niacin (Nicotinic Acid)FDA LinkGeneric
02/2015
1S 6 (S-6)IBA
02/2015
1HDL CholesterolIBA
07/2014
1PF-04445597IBA
07/2014
1AldosteroneIBA
07/2014
1Cholesterol Ester Transfer ProteinsIBA
07/2014
1Glucagon Receptors (Glucagon Receptor)IBA
02/2014
1Benzoic Acid (Potassium Benzoate)FDA Link
11/2013
15- (N- (4- ((4- ethylbenzyl)thio)phenyl)sulfamoyl)- 2- methylbenzoic acidIBA
11/2013
1PPAR alphaIBA
11/2013
1Biological ProductsIBA
01/2013
1Transaminases (Aminotransferases)IBA
10/2012
1Felbamate (Felbatol)FDA Link
10/2012
1acrylic acid (acrylate)IBA
10/2012

Therapy/Procedure

2Therapeutics
12/2021 - 01/2017